Pancreatic cancer is the most lethal common solid malignancy. Systemic therapies are often
ineffective, and predictive biomarkers to guide treatment are urgently needed. We generated …

Despite evidence that the intestinal microbiota (IM) is involved in the pathogenesis of
obesity, the IM composition of patients with nonalcoholic fatty liver disease (NAFLD) has not …

Purpose: To perform real-time whole genome sequencing (WGS) and RNA sequencing
(RNASeq) of advanced pancreatic ductal adenocarcinoma (PDAC) to identify predictive …

Pancreatic adenocarcinoma presents as a spectrum of a highly aggressive disease in
patients. The basis of this disease heterogeneity has proved difficult to resolve due to poor …

Intratumoral heterogeneity is a critical frontier in understanding how the tumor
microenvironment (TME) propels malignant progression. Here, we deconvolute the human …

Myocardial tagging is a new noninvasive MRI method that allows the study of myocardial
motion with high accuracy. However, with conventional tagging techniques tagging contrast …

Importance The US Preventive Services Task Force (USPSTF) is updating its 2008
colorectal cancer (CRC) screening recommendations. Objective To inform the USPSTF by …

Background & Aims Non-alcoholic fatty liver disease (NAFLD) is characterized by dysbiosis.
The bidirectional effects between intestinal microbiota (IM) and bile acids (BA) suggest that …

Purpose: To determine the impact of basal-like and classical subtypes in advanced
pancreatic ductal adenocarcinoma (PDAC) and to explore GATA6 expression as a surrogate …

OBJECTIVES: Laboratory and pathological predictors of future histological progression in
primary biliary cirrhosis (PBC) are needed for routine practice and clinical trials. We sought …