Epstein–Barr virus infection and nasopharyngeal carcinoma

SW Tsao, CM Tsang, KW Lo - … Transactions of the …, 2017 - royalsocietypublishing.org
Epstein–Barr virus (EBV) is associated with multiple types of human cancer, including
lymphoid and epithelial cancers. The closest association with EBV infection is seen in …

The role of Epstein–Barr virus in epithelial malignancies

SW Tsao, CM Tsang, KF To, KW Lo - The Journal of pathology, 2015 - Wiley Online Library
The close association of Epstein–Barr virus (EBV) infection with non‐keratinizing
nasopharyngeal carcinomas and a subset of gastric carcinomas suggests that EBV infection …

The significance of LMP1 expression in nasopharyngeal carcinoma

SW Tsao, G Tramoutanis, CW Dawson, AKF Lo… - Seminars in cancer …, 2002 - Elsevier
The Epstein–Barr virus (EBV)-encoded latent membrane protein 1 (LMP1) is a key effector of
EBV-mediated B cell transformation. LMP1 displays potent oncogenic properties in rodent …

[HTML][HTML] Proinflammatory cytokine responses induced by influenza A (H5N1) viruses in primary human alveolar and bronchial epithelial cells

MCW Chan, CY Cheung, WH Chui, SW Tsao… - Respiratory …, 2005 - Springer
Background Fatal human respiratory disease associated with influenza A subtype H5N1 has
been documented in Hong Kong, and more recently in Vietnam, Thailand and Cambodia …

Tropism, replication competence, and innate immune responses of the coronavirus SARS-CoV-2 in human respiratory tract and conjunctiva: an analysis in ex-vivo and …

KPY Hui, MC Cheung, RAPM Perera, KC Ng… - The Lancet …, 2020 - thelancet.com
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in
December 2019, causing a respiratory disease (coronavirus disease 2019, COVID-19) of …

[HTML][HTML] The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial …

LB Song, J Li, WT Liao, Y Feng, CP Yu… - The Journal of …, 2009 - Am Soc Clin Investig
The polycomb group protein B lymphoma Mo-MLV insertion region 1 homolog (Bmi-1) is
dysregulated in various cancers, and its upregulation strongly correlates with an invasive …

An Epstein-Barr virus–encoded microRNA targets PUMA to promote host cell survival

EYW Choy, KL Siu, KH Kok, RWM Lung… - The Journal of …, 2008 - rupress.org
Epstein-Barr virus (EBV) is a herpesvirus associated with nasopharyngeal carcinoma (NPC),
gastric carcinoma (GC), and other malignancies. EBV is the first human virus found to …

Tropism of avian influenza A (H5N1) in the upper and lower respiratory tract

JM Nicholls, MCW Chan, WY Chan, HK Wong… - Nature medicine, 2007 - nature.com
Poor human-to-human transmission of influenza A H5N1 virus has been attributed to the
paucity of putative sialic acid α2-3 virus receptors in the epithelium of the human upper …

The M, E, and N structural proteins of the severe acute respiratory syndrome coronavirus are required for efficient assembly, trafficking, and release of virus-like …

YL Siu, KT Teoh, J Lo, CM Chan, F Kien… - Journal of …, 2008 - Am Soc Microbiol
The production of virus-like particles (VLPs) constitutes a relevant and safe model to study
molecular determinants of virion egress. The minimal requirement for the assembly of VLPs …

[HTML][HTML] Exome and genome sequencing of nasopharynx cancer identifies NF-κB pathway activating mutations

YY Li, GTY Chung, VWY Lui, KF To, BBY Ma… - Nature …, 2017 - nature.com
Nasopharyngeal carcinoma (NPC) is an aggressive head and neck cancer characterized by
Epstein-Barr virus (EBV) infection and dense lymphocyte infiltration. The scarcity of NPC …