User profiles for "author:Soo Yong Tan"

Soo-Yong Tan

Associate Professor, National University of Singapore
Verified email at nus.edu.sg
Cited by 4226

Improving pathology and laboratory medicine in low-income and middle-income countries: roadmap to solutions

S Sayed, W Cherniak, M Lawler, SY Tan, W El Sadr… - The Lancet, 2018 - thelancet.com
Insufficient awareness of the centrality of pathology and laboratory medicine (PALM) to a
functioning health-care system at policy and governmental level, with the resultant …

Pharmacological significance of the non-canonical NF-κB pathway in tumorigenesis

D Morgan, M Garg, V Tergaonkar, SY Tan… - Biochimica et Biophysica …, 2020 - Elsevier
The understanding of the impact of the non-canonical NF-κB (nuclear factor kappa-light-
chain-enhancer of activated B cells) pathway in several human diseases including …

Epstein–Barr virus-associated T-and NK-cell lymphoproliferative diseases: an update and diagnostic approach

SSS Hue, ML Oon, S Wang, SY Tan, SB Ng - Pathology, 2020 - Elsevier
Summary Epstein–Barr virus (EBV)-positive T-cell and natural killer (NK)-cell
lymphoproliferative diseases (EBV-TNKLPD) are a group of uncommon disorders …

MYC regulates the core pre-mRNA splicing machinery as an essential step in lymphomagenesis

CM Koh, M Bezzi, DHP Low, WX Ang, SX Teo… - Nature, 2015 - nature.com
Deregulated expression of the MYC transcription factor occurs in most human cancers and
correlates with high proliferation, reprogrammed cellular metabolism and poor prognosis …

Janus kinase 3–activating mutations identified in natural killer/T-cell Lymphoma

GC Koo, SY Tan, T Tang, SL Poon, GE Allen, L Tan… - Cancer discovery, 2012 - AACR
The molecular pathogenesis of natural killer/T-cell lymphoma (NKTCL) is not well
understood. We conducted whole-exome sequencing and identified Janus kinase 3 (JAK3) …

Oncogenic activation of the STAT3 pathway drives PD-L1 expression in natural killer/T-cell lymphoma

TL Song, ML Nairismägi, Y Laurensia… - Blood, The Journal …, 2018 - ashpublications.org
Mature T-cell lymphomas, including peripheral T-cell lymphoma (PTCL) and extranodal
NK/T-cell lymphoma (NKTL), represent a heterogeneous group of non-Hodgkin lymphomas …

Expression of the FAT10 gene is highly upregulated in hepatocellular carcinoma and other gastrointestinal and gynecological cancers

CGL Lee, J Ren, ISY Cheong, KHK Ban, LLPJ Ooi… - Oncogene, 2003 - nature.com
The ubiquitin-like modifier (UBL) family has recently generated much interest in the scientific
community, as it is implicated to play important regulatory roles via novel protein–protein …

[HTML][HTML] Antisense oligonucleotide–mediated MDM4 exon 6 skipping impairs tumor growth

M Dewaele, T Tabaglio, K Willekens… - The Journal of …, 2016 - Am Soc Clin Investig
MDM4 is a promising target for cancer therapy, as it is undetectable in most normal adult
tissues but often upregulated in cancer cells to dampen p53 tumor-suppressor function. The …

Targeting of the MNK–eIF4E axis in blast crisis chronic myeloid leukemia inhibits leukemia stem cell function

S Lim, TY Saw, M Zhang, MR Janes… - Proceedings of the …, 2013 - National Acad Sciences
Chronic myeloid leukemia responds well to therapy targeting the oncogenic fusion protein
BCR-ABL1 in chronic phase, but is resistant to treatment after it progresses to blast crisis …

[PDF][PDF] Simultaneous inhibition of PI3Kδ and PI3Kα induces ABC-DLBCL regression by blocking BCR-dependent and-independent activation of NF-κB and AKT

J Paul, M Soujon, AM Wengner, S Zitzmann-Kolbe… - Cancer cell, 2017 - cell.com
Compared with follicular lymphoma, high PI3Kα expression was more prevalent in diffuse
large B cell lymphoma (DLBCL), although both tumor types expressed substantial PI3Kδ …