Substantial evidence points to a critical role for the p300/CREB binding protein (CBP)
coactivators in p53 responses to DNA damage. p300/CBP and the associated protein P/CAF …

By virtue of its ability to regulate both protein turnover and non-proteolytic signalling
functions, ubiquitin protein conjugation has been implicated in the control of multiple cellular …

Tumors are complex cellular and acellular environments within which cancer clones are
under continuous selection pressures. Cancer cells are in a permanent mode of interaction …

The adenovirus E1A and SV40 large-T-antigen oncoproteins bind to members of the
p300/CBP transcriptional coactivator family. Binding of p300/CBP is implicated in the …

PTEN is a tumor suppressor protein that functions, in large part, by dephosphorylating the
lipid second messenger phosphatidylinositol 3, 4, 5-trisphosphate and by doing so …

Rapid turnover of the tumor suppressor protein p53 requires the MDM2 ubiquitin ligase, and
both interact with p300–CREB-binding protein transcriptional coactivator proteins. p53 is …

Abstract Yin Yang 1 (YY1) is a transcription factor that plays an essential role in
development. However, the full spectrum of YY1's functions and mechanism of action …

Control of p53 turnover is critical to p53 function. E1A binding to p300/CBP translates into
enhanced p53 stability, implying that these coactivator proteins normally operate in p53 …

Epstein-Barr virus nuclear antigen 2 (EBNA-2) plays an essential role in primary B-
lymphocyte growth transformation. EBNA-2 is an acidic transcriptional transactivator that is …

The dominant transcriptional regulator of the papiIlomaviruses, E2, binds to its specific DNA
target through a previously unobserved dimeric ant i para I lei β-barrel. The DNA is severely …