[HTML][HTML] Biomarkers for homologous recombination deficiency in cancer

S Wagener-Ryczek, S Merkelbach-Bruse… - Journal of Personalized …, 2021 - mdpi.com
DNA double-strand breaks foster tumorigenesis and cell death. Two distinct mechanisms
can be activated by the cell for DNA repair: the accurate mechanism of homologous …

[HTML][HTML] Detection of gene fusions using targeted next-generation sequencing: a comparative evaluation

C Heydt, CB Wölwer, O Velazquez Camacho… - BMC medical …, 2021 - Springer
Background Gene fusions represent promising targets for cancer therapy in lung cancer.
Reliable detection of multiple gene fusions is therefore essential. Methods Five …

[HTML][HTML] Cancer-specific immune evasion and substantial heterogeneity within cancer types provide evidence for personalized immunotherapy

M Thelen, K Wennhold, J Lehmann… - npj precision …, 2021 - nature.com
The immune response against cancer is orchestrated by various parameters and site-
dependent specificities have been poorly investigated. In our analyses of ten different …

[HTML][HTML] Resistance to MET inhibition in MET-dependent NSCLC and therapeutic activity after switching from type I to type II MET inhibitors

R Riedel, J Fassunke, HL Tumbrink, AH Scheel… - European Journal of …, 2023 - Elsevier
Objectives Resistance to MET inhibition occurs inevitably in MET-dependent non-small cell
lung cancer and the underlying mechanisms are insufficiently understood. We describe …

Predictive molecular pathology in the time of coronavirus disease (COVID-19) in Europe

U Malapelle, P Pisapia, A Iaccarino… - Journal of Clinical …, 2021 - jcp.bmj.com
Aims Lung cancer predictive biomarker testing is essential to select advanced-stage patients
for targeted treatments and should be carried out without delays even during health …

[HTML][HTML] Transcriptome analysis reveals upregulation of immune response pathways at the invasive tumour front of metastatic seminoma germ cell tumours

T Nestler, P Dalvi, F Haidl, M Wittersheim… - British Journal of …, 2022 - nature.com
Background Testicular germ cell tumours (TGCTs) have a high metastasis rate. However,
the mechanisms related to their invasion, progression and metastasis are unclear …

MET fusions in NSCLC: Clinicopathologic features and response to MET inhibition

R Riedel, J Fassunke, AH Scheel, M Scheffler… - Journal of Thoracic …, 2024 - Elsevier
Introduction MET fusions have been described only rarely in NSCLC. Thus, data on patient
characteristics and treatment response are limited. We here report histopathologic data …

Immune-phenotyping of pleomorphic dermal sarcomas suggests this entity as a potential candidate for immunotherapy

S Klein, C Mauch, S Wagener-Ryczek… - Cancer Immunology …, 2019 - Springer
Background Pleomorphic dermal sarcomas (PDS) are sarcomas of the skin with local
recurrences in up to 28% of cases, and distant metastases in up to 20%. Although recent …

[HTML][HTML] Immune profile and immunosurveillance in treatment-naive and neoadjuvantly treated esophageal adenocarcinoma

S Wagener-Ryczek, M Schoemmel, M Kraemer… - Cancer Immunology …, 2020 - Springer
The outcome in esophageal adenocarcinoma (EAC) is still poor with only 20% of patients in
Western populations surviving for more than 5 years. Almost nothing is known about the …

[HTML][HTML] KEAP1/NFE2L2 Pathway Signature Outperforms KEAP1/NFE2L2 Mutation Status and Reveals Alternative Pathway-Activating Mutations in NSCLC

C Arolt, M Dugan, R Wild, V Richartz, B Holz… - Journal of Thoracic …, 2023 - Elsevier
Introduction Activation of the antioxidant KEAP1/NFE2L2 (NRF2) pathway leads to
increased glutamine dependence and an aggressive phenotype in NSCLC. Because this …