Background Patients with non-small-cell lung cancer sometimes show a dramatic clinical
response to gefitinib or erlotinib, small-molecule tyrosine kinase inhibitors (TKI) specific for …

Characterizing the relationship between the pharmacokinetics (PK, concentration vs. time)
and pharmacodynamics (PD, effect vs. time) is an important tool in the discovery and …

Recent progress in the studies of the olfactory system, especially in the molecular biological
studies, makes it one of the useful sensory model systems for understanding neural …

The epidermal growth factor receptor (EGFR) kinase inhibitors gefitinib and erlotinib are
effective treatments for lung cancers with EGFR activating mutations, but these tumors …

Recently it has been reported that mutations in the tyrosine kinase domain of the epidermal
growth factor receptor (EGFR) gene occur in a subset of patients with lung cancer showing a …

Purpose To evaluate the relationship between mutations of the epidermal growth factor
receptor (EGFR) gene and the effectiveness of gefitinib treatment in patients with recurrent …

Purpose: Non–small cell lung cancers carrying activating mutations in the gene for the
epidermal growth factor receptor (EGFR) are highly sensitive to EGFR-specific tyrosine …

To clarify the alterations of tau, amyloid β protein (Aβ) 1–40 and Aβ1–42 (43) in the
cerebrospinal fluid (CSF) that accompany normal aging and the progression of Alzheimer's …

Parvalbumin (PV)-immunoreactive neurons in rat neostriatum were studied under light and
electron microscopes. a small number of neurons in the striatum were immunoreactive for …

We revealed the structural features of astrocytes by means of light microscopy, confocal
laser scanning microscopy and high voltage electron microscopy, and estimated their …