Biological and clinical implications of EGFR mutations in lung cancer
T Mitsudomi, T Kosaka, Y Yatabe - International journal of clinical …, 2006 - Springer
Background Patients with non-small-cell lung cancer sometimes show a dramatic clinical
response to gefitinib or erlotinib, small-molecule tyrosine kinase inhibitors (TKI) specific for …
response to gefitinib or erlotinib, small-molecule tyrosine kinase inhibitors (TKI) specific for …
[HTML][HTML] Implementation of pharmacokinetic and pharmacodynamic strategies in early research phases of drug discovery and development at Novartis Institute of …
T Tuntland, B Ethell, T Kosaka, F Blasco… - Frontiers in …, 2014 - frontiersin.org
Characterizing the relationship between the pharmacokinetics (PK, concentration vs. time)
and pharmacodynamics (PD, effect vs. time) is an important tool in the discovery and …
and pharmacodynamics (PD, effect vs. time) is an important tool in the discovery and …
How simple is the organization of the olfactory glomerulus?: the heterogeneity of so-called periglomerular cells
K Kosaka, K Toida, Y Aika, T Kosaka - Neuroscience research, 1998 - Elsevier
Recent progress in the studies of the olfactory system, especially in the molecular biological
studies, makes it one of the useful sensory model systems for understanding neural …
studies, makes it one of the useful sensory model systems for understanding neural …
MET Amplification Leads to Gefitinib Resistance in Lung Cancer by Activating ERBB3 Signaling
…, CM Gale, X Zhao, J Christensen, T Kosaka… - science, 2007 - science.org
The epidermal growth factor receptor (EGFR) kinase inhibitors gefitinib and erlotinib are
effective treatments for lung cancers with EGFR activating mutations, but these tumors …
effective treatments for lung cancers with EGFR activating mutations, but these tumors …
Mutations of the Epidermal Growth Factor Receptor Gene in Lung Cancer: Biological and Clinical Implications
T Kosaka, Y Yatabe, H Endoh, H Kuwano, T Takahashi… - Cancer research, 2004 - AACR
Recently it has been reported that mutations in the tyrosine kinase domain of the epidermal
growth factor receptor (EGFR) gene occur in a subset of patients with lung cancer showing a …
growth factor receptor (EGFR) gene occur in a subset of patients with lung cancer showing a …
Mutations of the epidermal growth factor receptor gene predict prolonged survival after gefitinib treatment in patients with non–small-cell lung cancer with …
T Mitsudomi, T Kosaka, H Endoh, Y Horio… - Journal of Clinical …, 2005 - ascopubs.org
Purpose To evaluate the relationship between mutations of the epidermal growth factor
receptor (EGFR) gene and the effectiveness of gefitinib treatment in patients with recurrent …
receptor (EGFR) gene and the effectiveness of gefitinib treatment in patients with recurrent …
Analysis of Epidermal Growth Factor Receptor Gene Mutation in Patients with Non–Small Cell Lung Cancer and Acquired Resistance to Gefitinib
T Kosaka, Y Yatabe, H Endoh, K Yoshida, T Hida… - Clinical Cancer …, 2006 - AACR
Purpose: Non–small cell lung cancers carrying activating mutations in the gene for the
epidermal growth factor receptor (EGFR) are highly sensitive to EGFR-specific tyrosine …
epidermal growth factor receptor (EGFR) are highly sensitive to EGFR-specific tyrosine …
Longitudinal study of cerebrospinal fluid levels of tau, Aβ1–40, and Aβ1–42 (43) in Alzheimer's disease: a study in Japan
…, H Sasaki, K Abe, T Iwatsubo, T Kosaka… - Annals of Neurology …, 1998 - Wiley Online Library
To clarify the alterations of tau, amyloid β protein (Aβ) 1–40 and Aβ1–42 (43) in the
cerebrospinal fluid (CSF) that accompany normal aging and the progression of Alzheimer's …
cerebrospinal fluid (CSF) that accompany normal aging and the progression of Alzheimer's …
Parvalbumin-immunoreactive neurons in the rat neostriatum: a light and electron microscopic study
H Kita, T Kosaka, CW Heizmann - Brain research, 1990 - Elsevier
Parvalbumin (PV)-immunoreactive neurons in rat neostriatum were studied under light and
electron microscopes. a small number of neurons in the striatum were immunoreactive for …
electron microscopes. a small number of neurons in the striatum were immunoreactive for …
Structural and quantitative analysis of astrocytes in the mouse hippocampus
K Ogata, T Kosaka - Neuroscience, 2002 - Elsevier
We revealed the structural features of astrocytes by means of light microscopy, confocal
laser scanning microscopy and high voltage electron microscopy, and estimated their …
laser scanning microscopy and high voltage electron microscopy, and estimated their …