BackgroundSchizophrenia affects 1% of the population. Clozapine is the only medication
licensed for treatment-resistant schizophrenia and is intensively monitored to prevent harm …

Background A wealth of evidence obtained using mouse models indicates that CD4+
CD25+ FOXP3+ regulatory T cells (Treg) maintain peripheral tolerance to self-antigens and …

Background The genetic cause of primary immunodeficiency disease (PID) carries
prognostic information. Objective We conducted a whole-genome sequencing study …

Background There is indirect evidence that T cell responses can control the metastatic
spread of colorectal cancer (CRC). However, an enrichment of CD4+ Foxp3+ regulatory T …

Background An increasing number of NFKB1 variants are being identified in patients with
heterogeneous immunologic phenotypes. Objective To characterize the clinical and cellular …

Background: Allergy is diagnosed from typical symptoms, and tests are performed to
incriminate the suspected precipitant. Skin prick tests (SPTs) are commonly performed …

Objective: Alemtuzumab is potentially a highly effective treatment for relapsing multiple
sclerosis (MS) acting via complement-mediated lysis of circulating lymphocytes. Variability in …

CD68 is a transmembrane glycoprotein expressed in all cells of the mononuclear phagocyte
lineage including monocytes and tissue resident macrophages. Deletion analysis of the 5 …

Background Serological assays for Severe Acute Respiratory Syndrome Coronavirus 2
(SARS-CoV-2) have roles in seroepidemiology, convalescent plasma-testing, antibody …

Background Patients with primary antibody deficiency (PAD) are at increased risk of
respiratory tract infections, but our understanding of their nature and consequences remains …