The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs

U Wellner, J Schubert, UC Burk, O Schmalhofer… - Nature cell …, 2009 - nature.com
Invasion and metastasis of carcinomas is promoted by the activation of the
embryonic'epithelial to mesenchymal transition'(EMT) program, which triggers cellular …

The lymph node ratio is the strongest prognostic factor after resection of pancreatic cancer

H Riediger, T Keck, U Wellner, A Zur Hausen… - Journal of …, 2009 - Elsevier
Introduction Survival after surgery of pancreatic cancer is still poor, even after curative
resection. Some prognostic factors like the status of the resection margin, lymph node (LN) …

Mutant KRAS-driven cancers depend on PTPN11/SHP2 phosphatase

DA Ruess, GJ Heynen, KJ Ciecielski, J Ai… - Nature medicine, 2018 - nature.com
The ubiquitously expressed non-receptor protein tyrosine phosphatase SHP2, encoded by
PTPN11, is involved in signal transduction downstream of multiple growth factor, cytokine …

[HTML][HTML] ESOPEC: prospective randomized controlled multicenter phase III trial comparing perioperative chemotherapy (FLOT protocol) to neoadjuvant …

J Hoeppner, F Lordick, T Brunner, T Glatz, P Bronsert… - BMC cancer, 2016 - Springer
Background Recent randomized controlled trials comparing neoadjuvant chemoradiation
plus surgery or perioperative chemotherapy plus surgery with surgery alone showed …

Management of delayed visceral arterial bleeding after pancreatic head resection

F Makowiec, H Riediger, W Euringer, M Uhl… - Journal of …, 2005 - Springer
Despite low mortality, postoperative complications are still relatively frequent after pancreatic
head resection. The occurrence of delayed visceral arterial bleeding from erosions or …

Risk factors for complications after pancreatic head resection

U Adam, F Makowiec, H Riediger, WD Schareck… - The American Journal of …, 2004 - Elsevier
BACKGROUND: Postoperative morbidity is high after pancreatic head resections. Data
about risk factors are controversial. The aim of this study was to evaluate risk factors for …

[HTML][HTML] A simple scoring system based on clinical factors related to pancreatic texture predicts postoperative pancreatic fistula preoperatively

UF Wellner, G Kayser, H Lapshyn, O Sick, F Makowiec… - Hpb, 2010 - Elsevier
Background Postoperative pancreatic fistula (POPF) is regarded as the most serious
complication of pancreatic surgery. The preoperative risk stratification of patients by simple …

Postoperative morbidity and long-term survival after pancreaticoduodenectomy with superior mesenterico-portal vein resection

H Riediger, F Makowiec, E Fischer, U Adam… - Journal of …, 2006 - Springer
The role of superior mesenteric-portal vein resection (SM-PVR) for vein invasion or tumor
adherence during pancreatoduodenectomy (PD) is still under debate. We investigated …

ZEB 1‐associated drug resistance in cancer cells is reversed by the class I HDAC inhibitor mocetinostat

S Meidhof, S Brabletz, W Lehmann… - EMBO molecular …, 2015 - embopress.org
Therapy resistance is a major clinical problem in cancer medicine and crucial for disease
relapse and progression. Therefore, the clinical need to overcome it, particularly for …

Nonoperative treatment of 15 benign esophageal perforations with self-expandable covered metal stents

A Fischer, O Thomusch, S Benz… - The Annals of thoracic …, 2006 - Elsevier
BACKGROUND: Spontaneous or iatrogenic esophageal perforations after endoscopic
procedures are potentially life-threatening events with a considerable mortality rate. The aim …