Role of anaerobic bacteria in the metabolic welfare of the colonic mucosa in man.

WE Roediger - Gut, 1980 - gut.bmj.com
Suspensions of isolated epithelial cells (colonocytes) from the human colon were used to
assess utilisation of respiratory fuels which are normally available to the colonic mucosa in …

Metabolic induction of experimental ulcerative colitis by inhibition of fatty acid oxidation.

WE Roediger, S Nance - British journal of experimental pathology, 1986 - ncbi.nlm.nih.gov
There is some evidence that failure of fatty acid or beta-oxidation in the epithelium of the
colonic mucosa is associated with the development of ulcerative colitis. We tested the …

Short chain fatty acids as metabolic regulators of ion absorption in the colon.

WE Roediger - Acta Veterinaria Scandinavica. Supplementum, 1989 - europepmc.org
Between 50%-80% of sodium absorption in the colonic mucosa is dependent upon CO2
generation from SCFAs derived from the colonic lumen. Lumenal starvation leading to …

Method of preparing isolated colonic epithelial cells (colonocytes) for metabolic studies.

WE Roediger, SC Truelove - Gut, 1979 - gut.bmj.com
Suspensions of isolated colonic epithelial cells (colonocytes) have been obtained from rats
by incubating everted lengths of colon with EDTA at 37 degrees C in Krebs-Henseleit saline …

Impaired sulphation of phenol by the colonic mucosa in quiescent and active ulcerative colitis.

BS Ramakrishna, IC Roberts-Thomson, PR Pannall… - Gut, 1991 - gut.bmj.com
Substantial amounts of phenols are produced in the human colon by bacterial fermentation
of protein. In the colonic mucosa of animals, phenols are inactivated predominantly by …

Luminal ions and short chain fatty acids as markers of functional activity of the mucosa in ulcerative colitis.

WE Roediger, M Heyworth, P Willoughby… - Journal of Clinical …, 1982 - jcp.bmj.com
Luminal concentrations of short chain fatty acids (SCFA), ammonia, sodium and potassium
were measured in colonic dialysate of 16 control subjects and in 65 cases with ulcerative …

Estimation of phenolic conjugation by colonic mucosa.

BS Ramakrishna, D Gee, A Weiss, P Pannall… - Journal of clinical …, 1989 - jcp.bmj.com
Conjugation of phenol by the colonic mucosa was assessed in vivo using dialysis tubing
containing 1.5 ml of 1 mmol/l acetaminophen (paracetamol) and 10 mmol/l butyrate. These …

Colonic bicarbonate output as a test of disease activity in ulcerative colitis.

WE Roediger, MJ Lawson, V Kwok, AK Grant… - Journal of clinical …, 1984 - jcp.bmj.com
No available test objectively measures impairment of function of the inflamed colonic
mucosa in ulcerative colitis. To study function we assessed rectal bicarbonate output by …

Inhibition of hepatocyte lipogenesis by nitric oxide donor: could nitric oxide regulate lipid synthesis?

WE Roediger, R Hems, D Wiggins, GF Gibbons - IUBMB life, 2004 - Wiley Online Library
Tissue lipogenesis is variably controlled by substrate supply and hormones. The possibility
that nitric oxide (NO) might regulate lipogenesis derives from the action of NO on coenzyme …

Pathogenesis and treatment of plunging ranulas.

WE Roediger, S Kay - Surgery, Gynecology & Obstetrics, 1977 - europepmc.org
Three patients with plunging ranula, two of which occurred spontaneously and one of which
followed removal of the submandibular gland, were treated by excision of the sublingual …