Roles of the receptor for advanced glycation endproducts in diabetes-induced vascular injury
H Yonekura, Y Yamamoto, S Sakurai… - Journal of …, 2005 - jstage.jst.go.jp
Diabetic patients have shorter life span and poorer Quality of Life mainly due to diabetic
vascular complications. Recent in vitro and in vivo studies have shown that advanced …
vascular complications. Recent in vitro and in vivo studies have shown that advanced …
[HTML][HTML] RAGE-mediated inflammation, type 2 diabetes, and diabetic vascular complication
Y Yamamoto, H Yamamoto - Frontiers in endocrinology, 2013 - frontiersin.org
Obesity is associated with inflammation and type 2 diabetes. Innate immune system
comprised of cellular and molecular components plays an important role in the inflammatory …
comprised of cellular and molecular components plays an important role in the inflammatory …
[HTML][HTML] Development and prevention of advanced diabetic nephropathy in RAGE-overexpressing mice
Y Yamamoto, I Kato, T Doi, H Yonekura… - The Journal of …, 2001 - Am Soc Clin Investig
Vascular complications arising from multiple environmental and genetic factors are
responsible for many of the disabilities and short life expectancy associated with diabetes …
responsible for many of the disabilities and short life expectancy associated with diabetes …
The AGE-RAGE system and diabetic nephropathy
S Sakurai, H Yonekura, Y Yamamoto… - Journal of the …, 2003 - journals.lww.com
As is diabetes itself, diabetic vasculopathy is a multifactor disease. Studies revealed
advanced glycation end products (AGE) as the major environmental account for vascular …
advanced glycation end products (AGE) as the major environmental account for vascular …
Novel splice variants of the receptor for advanced glycation end-products expressed in human vascular endothelial cells and pericytes, and their putative roles in …
H Yonekura, Y Yamamoto, S Sakurai… - Biochemical …, 2003 - portlandpress.com
The binding of advanced glycation end-products (AGE) to the receptor for AGE (RAGE) is
known to deteriorate various cell functions and is implicated in the pathogenesis of diabetic …
known to deteriorate various cell functions and is implicated in the pathogenesis of diabetic …
[HTML][HTML] The N-terminal domain of thrombomodulin sequesters high-mobility group-B1 protein, a novel antiinflammatory mechanism
K Abeyama, DM Stern, Y Ito… - The Journal of …, 2005 - Am Soc Clin Investig
Thrombomodulin (TM) is an endothelial anticoagulant cofactor that promotes thrombin-
mediated formation of activated protein C (APC). We have found that the N-terminal lectin …
mediated formation of activated protein C (APC). We have found that the N-terminal lectin …
[HTML][HTML] The receptor for advanced glycation end products is induced by the glycation products themselves and tumor necrosis factor-α through nuclear factor-κB, and …
N Tanaka, H Yonekura, S Yamagishi, H Fujimori… - Journal of Biological …, 2000 - ASBMB
The binding of advanced glycation end products (AGE) to the receptor for AGE (RAGE) is
known to deteriorate various cell functions and is implicated in the pathogenesis of diabetic …
known to deteriorate various cell functions and is implicated in the pathogenesis of diabetic …
Plasma level of endogenous secretory RAGE is associated with components of the metabolic syndrome and atherosclerosis
H Koyama, T Shoji, H Yokoyama… - … , and vascular biology, 2005 - Am Heart Assoc
Objectives—Advanced glycation endproducts, AGEs, and its specific receptor, RAGE, are
involved in diabetic vascular complications. Endogenous secretory RAGE, esRAGE, has …
involved in diabetic vascular complications. Endogenous secretory RAGE, esRAGE, has …
CCR5 plays a critical role in obesity-induced adipose tissue inflammation and insulin resistance by regulating both macrophage recruitment and M1/M2 status
H Kitade, K Sawamoto, M Nagashimada, H Inoue… - Diabetes, 2012 - Am Diabetes Assoc
CC motif chemokine receptor (CCR) 2 and its ligand, monocyte chemoattractant protein
(MCP)-1, are pivotal for adipose tissue macrophage (ATM) recruitment and the development …
(MCP)-1, are pivotal for adipose tissue macrophage (ATM) recruitment and the development …
[HTML][HTML] Advanced glycation end products-driven angiogenesis in vitro: induction of the growth and tube formation of human microvascular endothelial cells through …
S Yamagishi, H Yonekura, Y Yamamoto… - Journal of Biological …, 1997 - ASBMB
This study was undertaken to determine whether and how advanced glycation end products
(AGE), senescent macroproteins accumulated in various tissues under hyperglycemic …
(AGE), senescent macroproteins accumulated in various tissues under hyperglycemic …