Article Text
Abstract
Lymphoma of the salivary gland accounts for 5% of cases of extranodal lymphoma and 10% of malignant salivary gland tumours. Most primary salivary gland lymphomas are B marginal zone lymphomas arising on a background of sialadenitis associated with autoimmune disorders such as Sjorgen's syndrome. Primary T cell lymphoma of the salivary gland is rare. This report describes a case of primary T cell lymphoma arising in the parotid gland of an elderly white man, which was notable for its striking resemblance to a B cell extranodal marginal zone lymphoma. Immunohistochemistry and gene rearrangement studies confirmed the clonal T cell nature of the tumour. There was no molecular evidence of Epstein-Barr virus (EBV) infection of neoplastic or surroundings cells. Only 14 cases of primary T cell lymphoma of the salivary glands have been recorded in the literature, most being from the Orient and having extremely variable prognosis. Those with a T/natural killer cell phenotype are associated with EBV infection. This case highlights the fact that T cell lymphoma in the salivary gland can mimic closely the morphological features of B cell extranodal marginal zone lymphoma.
- salivary gland
- T cell lymphoma
- Epstein Barr virus
- ALK1, anaplastic lymphoma kinase antibody
- CHOP regimen, cyclophosphamide, hydroxydaunorubicin (adriamycin), oncovin (vincristine), and prednisolone
- EBER, Epstein-Barr virus encoded early nuclear RNA
- EBV, Epstein-Barr virus
- IgH, immunoglobulin heavy chain
- MACOP regimen, methotrexate, adriamycin (doxorubicin), cyclophosphamide, oncovin (vincristine), and prednisolone
- NHL, non-Hodgkin's lymphoma
- NK, natural killer
- PCR, polymerase chain reaction
- TCR, T cell receptor
- TdT, terminal deoxynucleotidyl transferase
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- ALK1, anaplastic lymphoma kinase antibody
- CHOP regimen, cyclophosphamide, hydroxydaunorubicin (adriamycin), oncovin (vincristine), and prednisolone
- EBER, Epstein-Barr virus encoded early nuclear RNA
- EBV, Epstein-Barr virus
- IgH, immunoglobulin heavy chain
- MACOP regimen, methotrexate, adriamycin (doxorubicin), cyclophosphamide, oncovin (vincristine), and prednisolone
- NHL, non-Hodgkin's lymphoma
- NK, natural killer
- PCR, polymerase chain reaction
- TCR, T cell receptor
- TdT, terminal deoxynucleotidyl transferase