In recent years, several automated analysers that prepare and stain blood smears have been introduced in clinical laboratories. Despite the use of instrumental settings based on physical characteristic of individual samples, traumatic injuries of neutrophil and lymphocytes can be observed. Some samples present a very high percentage of damaged cells, allowing the speculation that a cellular susceptibility may enhance mechanical traumatism. These artefacts can puzzle morphological evaluation in both traditional and digitised microscopy; in addition, unskilled operators can be misled.
- Peripheral blood smears
- light microscopy review
- leukocytes morphological changes
- granulocyte dysplasia
- automatic slide makers.
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Handling editor Mary Frances McMullin.
Contributors ALG, MF and VR planned and designed the study. YP, SS, LR, MB and FF performed laboratory work and evaluated the slides and the pictures on the pre-classification systems. PP, FB, ALG and VR revised the manuscript critically. MF, MF and FF analysed the data. MF and MF performed the statistical calculations. All authors read and approved the manuscript.
Competing interests None declared.
Provenance and peer review Not commissioned; externally peer reviewed.